RAF Typhoon fighter aircraft have conducted a mission with French aircraft in a combined operation targeting an subterranean weapons facility in Syria operated by the IS group, according to the UK's MoD.
The location, located using surveillance, was believed to be housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes utilized Paveway IV guided bombs to hit a several entry passages down to the site... initial indications indicate the target was engaged successfully," the ministry announced.
There was no indication of any civilian casualties in the strike on Saturday evening and each participating jet made a safe return, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - established extremist governance over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and resolve to operate in unison with our partners, to eradicate any resurgence of IS and their harmful and extremist ideologies in the area," UK Defence Secretary the minister said.
RAF aircraft have carried out surveillance missions over Syria to "deter any efforts to regroup" of the group subsequent to its routing at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to all the members of our armed forces involved in this operation for their professionalism and their courage," he said. "They were part of thousands of UK service members stationed over the festive period. This action, to take out dangerous terrorists who threaten our way of life, shows how British military are prepared to act, all year round, protecting the UK at home and influential overseas."
Last December, the United States armed forces conducted what it described as a "major assault" targeting Daesh sites in Syria, following an attack claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The UN reports IS still has roughly 5-7 thousand combatants in Syria and Iraq.